Effects of circadian rhythm in regulating immune function
10.7644/j.issn.1674-9960.2017.03.017
- VernacularTitle:昼夜节律在调控免疫系统功能中的作用
- Author:
Chen XING
;
Lun SONG
- Keywords:
circadian rhythm;
circadian clock;
clock controlled gene;
immune cells;
immune function
- From:
Military Medical Sciences
2017;41(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythms are endogenous 24 h variations found in virtually all physiological processes and behaviors, which are controlled by the transcriptional translational oscillator that consists of a series of core clock genes (bmal1, clock, cry and per) and clock controlled genes (rev-erbα, rorα, dbp, tef and hlf).Clock genes exist in immune organs, tissues and cells, leading to the immune cell function (migration and chemotaxis, phagocytosis, cytotoxicity and so on) and a variety of immune parameters (factor level of circulating immune cells and subsets of the relative and absolute number of cells) showing circadian rhythm changes, and playing an important role in maintaining immune homeostasis.In addition, some immune related diseases are closely correlated with circadian rhythms abnormalities.This paper will focus on the effect of circadian rhythms on immune functions and their roles in some immune related diseases.
