Abnormal expression of MiRNAs in nephroblastoma pathogenesis

VernacularTitle:miRNAs在肾母细胞瘤发病中异常表达的研究进展
Author: Xin SUN ; Qingguo ZHU
Keywords: MicroRNAs/ME; Wilms tumor/ME/ET; Review
From: Journal of Chinese Physician 2017;19(3):475-478
CountryChina
Language:Chinese
Abstract: Wilms' tumor is the most common kidney tumor in childhood.MicroRNAs (miRNAs) are about the size of 19-22 nucleotide sequences that exist widely in the non-coding RNA in eukaryotes,function primarily through combination with mRNA target base pairing causing target mRNA degradation or inhibition of translation,and then develop his inhibiting or promoting the role of tumor.Abnormal expressions of miRNAs can cause a lot of kidney diseases,such as chronic kidney disease,polycystic kidney disease,renal fibrosis and renal cancer.Wilms'tumor,abnormal expression of key genomes,such as miR-17-92,miR-185,miR-204,miR-48 anomalies and tumors are closely related.Paper of miRNAs in incidence of Wilms'tumor expression,and the possible role for future targeted gene targeted drug sites are reviewed.