Clinical value of 68Ga-PSMA-11 PET/CT in the diagnosis of castration-resistant prostate cancer
10.3760/cma.j.issn.2095-2848.2017.03.004
- VernacularTitle:68Ga-PSMA-11 PET/CT对去势抵抗性前列腺癌的诊断价值
- Author:
Shiming ZANG
;
Feng WANG
;
Yue HUANG
;
Chuan ZHANG
;
Xiaochen YAO
;
Can CUI
;
Pengjun ZHANG
;
Hongbin SUN
;
Ruipeng JIA
;
Tiannyu LI
- Keywords:
Prostatic neoplasms;
castration-resistant;
Positron-emission tomography;
Tomography;
X-ray computed;
Prostate-specific membrane antigen;
Gallium radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(3):142-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the role of 68Ga-N,N′-bis(2-hydroxy-5-(carboxyethyl)benzyl) ethylenediamine-N,N′-diacetic acid(HBED-CC)-(Ahx)Lys-CO-Glu(PSMA-11) PET/CT on the detection of metastatic lesions from castration-resistant prostate cancer (CRPC).Methods Sixteen patients with CRPC who underwent 68Ga-PSMA-11 PET/CT between January 2015 and November 2015 were recruited in this study.Mean age of patients was (72±9) years.The PSA levels were 4-12 356 μg/L, Gleason score was 7-10.PET/CT was performed at 1 h postinjection of 68Ga-PSMA-11.Patient-based analysis and lesion-based analysis were performed.ROI analysis was used to calculate the tumor uptake (SUVmax).Final diagnosis was based on histopathology and results of other imaging examinations(99Tcm-MDP imaging, MRI).χ2 test was used to compare the diagnostic efficiencies of PET and CT.Results No adverse effects were observed in patients.68Ga-PSMA-11 PET/CT showed moderate physiologic uptake in salivary glands and proximal small intestine, with predominant tracer clearance by the kidneys.All patients were positive on 68Ga-PSMA-11 PET/CT.Bone metastasis was found in 16 patients, liver metastasis in 2 patients (5 lesions), and lymph node metastasis in 4 patients (26 lesions).The SUVmax of liver, lymph node and bone metastases were 15.06±2.77, 7.54±5.20, 19.01±16.96, respectively.The diagnostic sensitivity, specificity and accuracy on bone metastasis with 68Ga-PSMA-11 PET and CT were 96.30%(52/54) vs 61.11%(33/54), 3/3 vs 1/3, 96.49%(55/57) vs 59.65%(34/57).The sensitivities and accuracies of the two modalities were significantly different(χ2=19.943, 22.593, both P<0.01).Conclusions 68Ga-PSMA-11 PET/CT could precisely detect both primary and metastatic lesions of CRPC, suggesting that it is of great value for the clinical management and treatment.
