Association between Helicobacter pylori infection and creatinine clearance rate in elderly hypertensive patients
10.3760/cma.j.issn.0254-9026.2017.03.017
- VernacularTitle:老年高血压患者幽门螺杆菌感染与肌酐清除率降低的关系
- Author:
Fanglian CHEN
;
Feng WANG
;
Minghui ZHAO
;
Ping LEI
- Keywords:
Hypertension;
Helicobacter pylori;
Metabolic clearance rate
- From:
Chinese Journal of Geriatrics
2017;36(3):297-299
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To reveal the association between Helicobacter pylori infection and creatinine clearance rate in elderly patients with hypertension.Methods A total of 600 elderly hypertensive patients with different degrees of renal impairment and helicobacter pylori(HP)infection were randomly selected from Department of Health Care,General Hospital of Tianjin Medical University from 2010 to 2015.Serum creatinine concentration detection was conducted and creatinine clearance rate was calculated.Patients were divided into HP infection group(n =254)and non-HP-infection group (n =346).The multiple logistic regression analysis showed the correlation between Helicobacter pylori infection and decreased creatinine clearance rate.Results Creatinine clearance rate was significantly lower in HP-infection group[(61.1 ± 12.7)ml/min] than in non-HP-infection group[(78.5 ± 11.9) ml/min,P =0.014].Multifactorial logistic analysis revealed that Helieobacter pylori infection was significantly associated with decreased creatinine clearance rate(OR=3.5 18,95 ％ CI:1.105～4.918,P =0.011).Conclusions Helicobacter pylori infection is significantly related with decreased creatinine clearance rate in elderly patients with hypertension.
