Recent progress in researching the reactive oxygen species-mediated myocardial remodeling
10.3760/cma.j.issn.0254-9026.2017.03.026
- VernacularTitle:活性氧介导心肌重构研究的新进展
- Author:
Yi SUN
;
Bao LI
;
Yuean ZHANG
;
Fuzhong QIN
- Keywords:
Oxidative Stress;
Cell aging;
Ventricular remodeling;
Heart failure
- From:
Chinese Journal of Geriatrics
2017;36(3):330-335
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen species(ROS) in the cardiac muscle are increased in cardiovascular diseases such as hypertension,coronary heart disease and heart failure.Oxidative stress mediates myocyte hypertrophy,myocyte apoptosis and interstitial fibrosis.And these changes are particularly pronounced in elderly patients or senescent animal disease models.The major sources of ROS in myocardium are mitochondria and the reduced nicotinamide adenine dinucleotide phosphate(NADPH) oxidase.Specific ROS such as hydrogen peroxide play an important role in myocardial remodeling in heart failure.Oxidative modifications of calcium handling proteins result in reduction of their activities,leading to decreased myocardial contractility.Reduction of oxidant levels and inhibition of oxidative modifications of specific proteins through inhibiting ROS sources may provide new strategies for the treatment of myocardial remodeling.
