Myokines and osteokines in muscle-bone interactions
10.3760/cma.j.issn.0254-9026.2017.03.029
- VernacularTitle:肌肉与骨骼相互作用中的肌源性和骨源性因子
- Author:
Dongmei CHEN
;
Kexiang ZHAO
;
Qian XIAO
- Keywords:
Muscular diseases;
Osteoporosis
- From:
Chinese Journal of Geriatrics
2017;36(3):344-347
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia and osteoporosis are two common diseases with adverse effects on the health of the elderly and share many characteristics.As target organs of the two diseases,muscles and bones are closely connected,not only in anatomy and physiology,but also in pathophysiological processes.Initially,mechanical stimulation was conducted to explain the relationship between muscle and bone at the macroscopic level.Currently,research is increasingly focused at the cellular and molecular levels.Both muscle and bone tissues can secrete a number of growth factors,cytokines,polypeptides,and so on.Myokines include fibroblast growth factor-2 (FGF-2),myostatin,irisin,insulinlike growth factor-1 (IGF-1),interleukins,musclin,among others.Osteokines comprise osteocalcin,fibroblast growth factor-23,IGF-1,vascular endothelial growth factor,etc.In this review,we summarize the roles of myokines and osteokines in muscle-bone interactions.
