A clinical analysis of subclinical hypothyroidism during pregnancy and the effect of thyroxine replacement therapy
10.3760/cma.j.issn.1000-6699.2017.03.005
- VernacularTitle:妊娠期亚临床甲状腺功能减退的临床分析及甲状腺激素替代治疗的效果观察
- Author:
Yueyue WU
;
Ling CHEN
;
Xinmei HUANG
;
Tiange SUN
;
Jun LIU
;
Min YANG
;
Rui ZHANG
;
Jiong XU
;
Li SHENG
;
Zaoping CHEN
;
Fang WANG
- Keywords:
Pregnancy;
Subclinical hypothyroidism;
Thyroxine;
Pregnancy outcome;
Perinatal events
- From:
Chinese Journal of Endocrinology and Metabolism
2017;33(3):198-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the maternal and fetal outcomes of pregnant women with subclinical hypothyroidism, and clinical observation of thyroxine replacement. Methods From March 2014 to March 2015, the clinical records of 216 women with subclinical hypothyroidism(including 166 cases with thyroxine replacement), and hypothyroidism(n=69)during pregnancy who delivered at our hospital were reviewed. The maternal complications and neonatal outcomes were compared with 406 healthy women who delivered during the same period. Results The age, number of fetus, and morbidity rate of gestational hypertension were without significant differences in those groups. The morbidity of gestational diabetes in subclinical hypothyroidism group and hypothyroidism group were significantly higher than those in control group(13.4%, 17.4% vs 0.2%, P<0.05). The rate of thyroid peroxidase antibody and thyroglobulin antibody positive in subclinical hypothyroidism group and hypothyroidism group were significantly higher than those in control group(26.9%, 23.2% vs 9.9%; 15.7%, 23.2% vs 8.1%, all P<0.05). No matter treated or not treated in subclinical hypothyroidism group, the preterm birth, Apgar score, low birth weight, birth defects, and infant congenital hypothyroidism were without significant differences as compared to the control group(P>0.05). Further compared those between treated and untreated subclinical hypothyroidism, the results were also without significant difference(P>0.05). Conclusions Subclinical hypothyroidism had no significant influence on pregnancy outcomes and perinatal events. Thyroxine replacement in subclinical hypothyroidism pregnant women also had no significant influence on pregnancy outcomes and perinatal events.
