Effect of rivaroxaban in preventing deep venous thrombosis after large orthopedic operation of lower extremity
10.7501/j.issn.1674-6376.2017.03.016
- VernacularTitle:利伐沙班预防骨科下肢大型手术后深静脉血栓的效果分析
- Author:
Changke XU
;
Zhihui WU
- Keywords:
rivaroxaban;
anticoagulation therapy;
DVT;
large orthopedic operation of lower extremity;
platelet;
hemoglobin;
D-dimer;
Hcy;
hs-CRP
- From:
Drug Evaluation Research
2017;40(3):369-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect ofrivaroxaban in preventing deep venous thrombosis after large orthopedic operation of lower extremity.Methods Totally 80 patients after lower extremity of large orthopedic operation were selected,they were divided into two groups randomly.The patients in control group (39 cases) were sc injected with enoxaparin through.The patients in observation group (41 cases) were given rivaroxaban orally.The effect of rivaroxaban in preventing deep venous thrombosis after large orthopedic operation of lower extremity were evaluated by hemodynamic indexes,diagnosis index,and complications during 1 months follow-up.Results Before operation,there was no statistical significance on platelet,hemoglobin,and PT values between two groups.Compared with the value before operation,the value ofplatelet and hemoglobin had no significantly change after 3 d of operation.But the PT was increased (P ＜ 0.05).After 3 d of operation,there was no statistical significance on platelet and hemoglobin between two groups.But the PT value of observation was higher than that of control group (P ＜ 0.05).After 1 h operation,there was no statistical significance on D-dimer,Hcy,and hs-CRP between two groups.Compared with the value after 1 h of operation,the values of D-dimer,Hcy,and hs-CRP were decreased significantly (P ＜ 0.05).And the indexes of observation group were lower than those of control group (P ＜ 0.05).After 1 months of operation,although there was no statistical significance on complications between two groups,the incidence rate of secondary bleeding and DVT of control group was higher than that of the observation group.Conclusion The rivaroxaban could prevent DVT well,which is suitable for the anticoagulation therapy after lower extremity of large orthopedic operation with little influence on platelet and hemoglobin.It is worthy of clinical application.
