The emerging role of nuclear factor erythroid 2-related factor 2 signaling pathway in diabetic chronic complications
10.3760/cma.j.issn.1000-6699.2017.03.002
- VernacularTitle:抗氧化的NRF2通路与糖尿病及其慢性并发症
- Author:
Min LONG
;
Hongting ZHENG
- Keywords:
Nuclear factor erythroid 2-related factor 2;
Diabetes mellitus;
Chronic complication;
Oxidative stress
- From:
Chinese Journal of Endocrinology and Metabolism
2017;33(3):185-189
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress played an important role in the development of diabetes and its complications. Nuclear factor erythroid 2-related factor 2 (NRF2) pathway is one of the most vital endogenous antioxidant pathways. Accumulated evidences indicated that the relationship between diabetes and NRF2 pathway attracted more and more attention in recent years. Our group has devoted ourselves to the researches concerning the chronic complications of diabetes and NRF2 pathways. This review highlighted our recent progresses in the underlying mechanism of the protective role of NRF2 in diabetic nephropathy, diabetic ulcers and diabetic amyotrophy. Finally, the possibility of NRF2 agonists applied to clinical therapy for diabetic chronic complications was explored.
