Reproductive factors for ovarian cancer in southern Chinese women.
10.3802/jgo.2013.24.2.135
- Author:
Maria PASALICH
1
;
Dada SU
;
Colin W BINNS
;
Andy H LEE
Author Information
1. School of Public Health, Curtin University, Perth, WA, Australia. Andy.Lee@curtin.edu.au
- Publication Type:Original Article
- Keywords:
China;
Oral contraceptives;
Ovarian cancer;
Parity
- MeSH:
Asian Continental Ancestry Group;
Breast;
Case-Control Studies;
Child;
China;
Contraceptives, Oral;
Female;
Hormone Replacement Therapy;
Humans;
Hysterectomy;
Logistic Models;
Odds Ratio;
Ovarian Neoplasms;
Parity;
Parturition;
Surveys and Questionnaires
- From:Journal of Gynecologic Oncology
2013;24(2):135-140
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate the association between reproductive factors and the risk of ovarian cancer among southern Chinese women. METHODS: A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, between 2006 and 2008. A structured questionnaire was used to obtain information on parity, oral contraceptive use and other reproductive factors in a sample of 500 incident ovarian cancer patients and 500 controls (mean age, 59 years). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression models. RESULTS: High parity was inversely associated with ovarian cancer, with an adjusted OR 0.43 (95% CI, 0.30 to 0.62) for women who had given birth to 3 or more children compared to women who had given no more than one birth. Ever use of oral contraceptives was also protective against ovarian cancer; adjusted OR 0.56 (95% CI, 0.40 to 0.78). No association was found for hormone replacement therapy, menopausal status, hysterectomy and family history of ovarian and/or breast cancer. CONCLUSION: High parity and oral contraceptive use are associated with a lower risk of ovarian cancer in southern Chinese women.
