Determination of eight heavy metal elements in iron dextran by inductively coupled plasma optical emission spectrometry and correction of spectral interference
10.7501/j.issn.1674-6376.2017.03.009
- VernacularTitle:电感耦合等离子体发射光谱法测定右旋糖酐铁中8种重金属元素及光谱干扰的校正
- Author:
Chao MA
;
Simeng FANG
;
Nan MI
;
Kexin ZANG
;
Mujun SU
- Keywords:
inductively coupled plasma optical emission spectrometry;
interference element correction;
spectral interference;
iron dextran;
heavy metal elements
- From:
Drug Evaluation Research
2017;40(3):335-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for the determination of eight heavy metal elements (Pb,Cd,As,Hg,Co,V,Se,and Mo) in iron dextran by inductively coupled plasma optical emission spectrometry (ICP-OES).Methods Through detection wavelength selection,optimization of instrument parameters and applying interference element correction (IEC) method to correction of spectral interference,the eight heavy metal elements were analyzed by ICP-OES.Results The elements recoveries were from 88.7％ to 101.3％ by correction of spectral interference with IEC method.The accuracy of the method was good.The linearities of the detected elements were good,and the correlation coefficients were all greater than 0.999.The detection limits were from 0.12 to 7.26 ng/rnL.The quantization limits were from 0.40 to 23.96 ng/mL.The precision of the method was good (RSD＜3.5％,n=6).Conclusion The results of the spectral interference correction by IEC method are greatly superior to the results of conventional method.The established method is accurate,sensitive,and rapid,which can be applied to the determination of contents of eight heavy metal elements in iron dextran.
