Clinical effect of atorvastatin combined with lopidogrel in patients with transient ischemic attack
10.7501/j.issn.1674-6376.2017.03.014
- VernacularTitle:阿托伐他汀联合氯吡格雷治疗短暂性脑缺血发作的临床研究
- Author:
Pengju GAO
;
Kai WANG
- Keywords:
transient ischemic attack;
atorvastatin;
lopidogrel;
effect;
hs-CPR;
Lp-PLA2
- From:
Drug Evaluation Research
2017;40(3):361-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of atorvastatin combined with lopidogrel in patients with transient ischemic attack.Methods Totally 92 cases of patients with transient ischemic attack in Xingyuan Hospital of Yulin City from January 2013 to August 2015 were divided into observation group and control group,46 cases in each group.Patients in observation group were treated with atorvastatin combined with lopidogrel,and patients in control group were treated with lopidogrel.The differences in short term effect,long-term effect,and adverse reaction between two groups were compared.Results The total effective rate of observation group was significantly higher than that of control group (P ＜ 0.05);After treatment,the levels of hs-CPR,Lp-PLA2TC,TG,and LDL,the recurrence rate of transient ischemic attack and the incidence of cerebral infarction of the observation group were significantly lower than that of the control group and before treatment (P ＜ 0.05),but the differences in PLT,PT,and APTT between two groups before and after treatment were not significant.Conclusion The clinical effect of atorvastatin combined with lopidogrel in patients with transient ischemic attack were remarkable,and the incidence of adverse events do not increase.
