Expression and significance of BCL-6 and ZEB2 in breast cancer
10.13315/j.cnki.cjcep.2017.01.013
- VernacularTitle:乳腺癌中BCL-6和ZEB2的表达及其意义
- Author:
Li ZHENG
;
Min ZHAO
;
Lin ANG
;
Jin HUANG
;
Jin WANG
;
Qiang ZOU
;
Zhengsheng WU
- Keywords:
breast neoplasm;
BCL-6;
ZEB2;
immunohistochemisty;
situ hybridization
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the biological significance of BCL-6 and ZEB2 in invasion,metastasis and prognosis of breast cancer.Methods The expressions of BCL-6,ZEB2 protein and mRNA were detected respectively in 228 cases of breast cancer and 80 cases of breast benign lesions by immunohistochemical SP two-step staining and situ hybridization.Result The expression levels of BCL-6,ZEB2 protein and mRNA in breast cancer tissues were significantly higher than in breast benign lesions (P ＜ 0.05).The expressions of BCL-6 was positively correlated with tumor size,lymphatic metastasis,histological grade,TNM staging and HER-2 expression (P ＜ 0.05).The expressions of ZEB2 was positively correlated with tumor size,lymphatic metastasis,TNM staging and HER-2 expression (P ＜ 0.05).The overall survival and relapse-free survival of BCL-6 and ZEB2 positive expression were significantly less than the negative expression (P ＜ 0.01).Conclusion The BCL-6 and ZEB2 are closely correlated with the evolution process of breast cancer,which may become important means for monitoring and warning the metastasis,invasion,and prognosis of breast cancer.
