Facial basal cell carcinoma: the relationship between clinicopathologic analysis and safety surgical margin
10.13315/j.cnki.cjcep.2017.01.017
- VernacularTitle:面部基底细胞癌临床病理分析及安全切缘的关系
- Author:
Ya ZHANG
;
Minggang WANG
;
Hangcheng ZHOU
- Keywords:
basal cell neoplasm;
histopathological type;
surgical margin;
intraoperative frozen section
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(1):68-72
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study clinical pathological characteristics,margin status and its influencing factors in different type of facial basal cell carcinoma (BCC).Methods The histopathological features,margin status of the first frozen section and influencing factors was retrospectively analyzed,with review of the relevant literature.The primary outcome variable was the rate of initially positive frozen section margins.Multivariable Logistic regression was used to study histologic subtype,surgical margins,tumor size,location and other factors influence on the rate of initially positive frozen section margins.Results The pathological subtype is the major risk factor,the infiltrative (OR =4.463,95％ CI =1.919-10.380,P ＜0.05) and morpheaform (OR=5.018,95％CI=2.025-16.623,P＜0.05) had higher risk on positive surgical margin compared with the nodular.The rate of initially positive frozen section margins of nodular and superficial BCC at different margins were observed but the difference were not significant (P ＞ 0.05).Conclusion The pathological subtype is the major risk factor.Surgical excision with a 3 mm margin can achieve ideal results for nodular and superficial BCC in facial area.
