Effects of Melilotus Extract Tablet on Postoperative Therapeutic Efficacy of Chronic Sinusitis Endoscopic Surgery and the Recovery of Nasal Mucosa
10.6039/j.issn.1001-0408.2017.11.26
- VernacularTitle:草木犀流浸液片对慢性鼻窦炎内镜术后患者的疗效及对鼻腔黏膜的修复作用
- Author:
Xianbo ZHU
;
Yu HUO
;
Anchun DENG
;
Xiaojun LIANG
- Keywords:
Sinusitis;
Nasal mucosa;
Endoscopic surgery;
Melilotus extract tablet;
Clinical efficacy;
Safety
- From:
China Pharmacy
2017;28(11):1529-1531
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Melilotus extract tablet on postoperative therapeutic efficacy of chronic sinusitis endoscopic surgery and the recovery of nasal mucosa. METHODS:The clinical data of 100 patients undergoing chronic si-nusitis functional endoscopic surgery in our hospital from May 2015 to Oct. 2016 were analyzed retrospectively and they were divid-ed into control group and observation group according to postoperative treatment,with 50 cases in each group. Two groups received anti-inflammatory,anti-histamine and hemostasis therapy. The control group received Eucalyptol,linonene and pinene enteric soft capsules 0.3 g,tid;observation group was additionally given Melilotus extract tablet 1.2 g,tid,for 6 weeks,on the basis of con-trol group. VAS and Lund-Kennedy endoscopic score were compared between 2 groups before and after treatment. Clinical effica-cies and the occurrence of ADR were also compared between 2 groups. RESULTS:there was no statistical significance in VAS score and its total score,Lund-Kennedy endoscopic score and its total score between 2 groups before treatment (P>0.05). After treatment,VAS score and its total score,Lund-Kennedy endoscopic score and its total score of 2 groups were significantly de-creased,and the observation group was significantly lower than the control group,with statistical significance(P<0.05). The cure rate of observation group was 72.0%,which was significantly higher than 44.0% of control group,with statistical significance (P<0.05). There was no significant difference in the incidence of adverse reactions between the 2 groups (P>0.05). CONCLU-SIONS:Melilotus extract tablet helps to improve clinical efficacy and the recovery of nasal mucosa in patients with chronic sinus-itis after endoscopic surgery,with good safety.
