Effects of Application Timing of Carboporst Tromethamine on Postpartum Hemorrhage and Hemodynam-ics of Cesarean Section Women with Central Placenta Previa
10.6039/j.issn.1001-0408.2017.11.28
- VernacularTitle:卡前列素氨丁三醇应用时机对中央性前置胎盘剖宫产妇产后出血及血流动力学的影响
- Author:
Qingsen HE
;
Jianmin YANG
- Keywords:
Placenta previa;
Cesarean section;
Carboporst tromethamine;
Application timing;
Hemodynamics;
Postpartum hemorrhage
- From:
China Pharmacy
2017;28(11):1535-1537
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of application timing of carboporst tromethamine on postpartum hemor-rhage and hemodynamics of cesarean section women with centralplacenta previa. METHODS:Totally 138 parturient women with central placenta previa selected from our hospital during Jan.-Dec. 2015 were divided into observation group and control group ac-cording to random number table,with 69 cases in each group. Both groups received cesarean section. Control group was given Car-boporst tromethamine injection 250 μg on uterine body after the delivery of placenta. Observation group was given Carboporst tro-methamine injection 250 μg on corpora uteri immediately after umbilical cord cutting. The operation duration,intraoperative and postoperative blood loss were observed in 2 groups. The preoperative and postoperative 24 h hemodynamic index,coagulation func-tion and corpora uteri were compared between 2 groups. RESULTS:The operation duration of observation group was significantly shorter than control group;intraoperative blood loss and 24h blood loss of observation group were significantly less than control group,with statistical significance(P<0.05). There was no statistical significance in preoperative hemodynamic index and coagula-tion function index between 2 groups before surgery(P>0.05). 24 h after surgery,SBP,DBP,MAP,FIB and D-D of 2 groups were decreased significantly,while HR of them were increased significantly;the observation group was significantly better than the control group,with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR (15.94% vs. 13.04%) between 2 groups (P>0.05). CONCLUSIONS:Carboporst tromethamine after omphalotomy via uterine body helps to shorten the operation time,reduce intraoperative blood loss,maintain hemodynamic indexes stable and improve coagulation func-tion of cesarean section women with central placenta previa ,with good safety.
