Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet.
- Author:
Ha Neul CHOI
1
;
Min Jung KANG
;
Soo Jin LEE
;
Jung In KIM
Author Information
- Publication Type:Original Article
- Keywords: Myricetin; obesity; glucose; insulin; inflammation
- MeSH: Adipose Tissue, White; Adiposity; Animals; Blood Glucose; Body Weight; Cytokines; Diabetes Mellitus, Type 2; Diet*; Eating; Glucose; Homeostasis; Humans; Hypercholesterolemia; Hypertriglyceridemia; Inflammation; Insulin; Insulin Resistance*; Interleukin-6; Leptin; Male; Mice*; Obesity; Risk Factors; Tumor Necrosis Factor-alpha; Weight Gain
- From:Nutrition Research and Practice 2014;8(5):544-549
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/OBJECTIVES: Obesity-associated insulin resistance is a strong risk factor for type 2 diabetes mellitus. The aim of this study was to investigate the effect of myricetin on adiposity, insulin resistance, and inflammatory markers in mice with diet-induced insulin resistance. MATERIALS/METHODS: Five-week-old male C57BL/6J mice were fed a basal diet, a high-fat, high-sucrose (HFHS) diet, or the HFHS diet containing 0.06% myricetin or 0.12% myricetin for 12 weeks after a 1-week adaptation, and body weight and food intake were monitored. After sacrifice, serum lipid profiles, glucose, insulin, adipocyte-derived hormones, and proinflammatory cytokines were measured. The homeostasis model assessment for insulin resistance (HOMA-IR) was determined. RESULTS: Myricetin given at 0.12% of the total diet significantly reduced body weight, weight gain, and epidydimal white adipose tissue weight, and improved hypertriglyceridemia and hypercholesterolemia without a significant influence on food intake in mice fed the HFHS diet. Serum glucose and insulin levels, as well as HOMA-IR values, decreased significantly by 0.12% myricetin supplementation in mice fed the HFHS diet. Myricetin given at 0.12% of the total diet significantly reduced serum levels of leptin, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in mice fed the HFHS diet. CONCLUSIONS: These findings suggest that myricetin may have a protective effect against diet-induced obesity and insulin resistance in mice fed HFHS diet, and that alleviation of insulin resistance could partly occur by improving obesity and reducing serum proinflammatory cytokine levels.
