Effects of L-carnitine on Inflammatory Factor,Oxidative Stress Index and Cardiac Function of Mainte-nance Hemodialysis Patients
10.6039/j.issn.1001-0408.2017.11.35
- VernacularTitle:左卡尼汀对维持性血液透析患者炎症因子、氧化应激指标及心脏功能的影响
- Author:
Haiping XU
;
Xiuli LI
;
Lina SUN
;
Fuyun SUN
- Keywords:
L-carnitine;
Maintenance hemodialysis;
Micro inflammatory state;
Inflammatory factor;
Oxidant stress index;
Cardiac function
- From:
China Pharmacy
2017;28(11):1558-1561
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of L-carnitine on inflammatory factor,oxidant stress index and cardiac func-tion in patients with maintenance hemodialysis. METHODS:One hundred and twenty maintenance hemodialysis patients selected from our hospital during Dec. 2014-Feb. 2016 were randomly divided into observation group and control group,with 60 cases in each group. Control group received maintenance hemodialysis for 1 month,and then was given rhEPO injection 3000 IU subcuta-neously,3 times a week. Observation group was additionally given Levocarnitine for injection 2 g,iv,qod,1 day after hemodialy-sis,on the basis of control group. Two groups were treated for consecutive 3 months. The levels of inflammatory factors (IL-6, TNF-α,CRP),oxidant stress indexes(MDA,GSH-Px,SOD)and cardiac function indexes(CO,LVEF,LVST)were observed in 2 groups before and after treatment;the occurrence of ADR was recorded. RESULTS:There was no statistical significance in in-flammatory factor,oxidant stress index and cardiac fuaction before treatment between 2 groups(P>0.05). After treatment,the lev-els of IL-6,TNF-α,CRP and MDA in observation group were decreased significantly,while the levels of GSH-Px,SOD,CO and LVEF were increased significantly,compared to before treatment;the improvement of above indexes in observation group were sig-nificantly better than control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups during treat-ment. CONCLUSIONS:L-carnitine can effectively alleviate the micro-inflammatory state in maintenance hemodialysis patients and protect myocardial function with good safety.
