Clinical research progress on tissue defect repairing with acellular dermal matrices

VernacularTitle:脱细胞真皮基质修复组织缺损研究进展
Author: Yingying LU ; Zheng XU ; Dongpeng WEN ; Guosheng WANG
Keywords: Acellular dermal matrix; Preparation; Clinical application
From: International Journal of Biomedical Engineering 2017;40(1):58-61
CountryChina
Language:Chinese
Abstract: Acellular dermal matrix(ADM) is a special biological material that contains only collagen,elastin and other extracellular matrix.ADMs are made by special methods of separating skin epidermis and dermis,and removing Laugerhans cells,vascular endothelial cells,fibrohlasts cells and major histocompatibility complex (MHC)within the dermis.ADM causes no graft rejection,and provides a good scaffold for tissue reconstruction,angiogenesis and implantation of host cells.The preparation process of ADM includes the separation of epidermis and dermis,decellularization,perforation and freeze-drying.According to the classification method,ADMs can be classified into allogeneic and xenogeneic ADM,patch and injection type ADM,as well as cross-linked and non-crosslinked ADM,which can meet various clinical requirements.ADM is widely used in surgical field,such as treatment of deep burn wounds,breast reconstruction after masteetomy,oral mucosa repair,abdominal wall hernia repair,and treatment of vocal cord paralysis.Due to the characteristics ADM,its application prospect is considerable.The research progress of ADM in recent years was summarized.