Expression of peripheral blood CD13+ CD4+ CD25hi regulatory T cells in patients with diffuse large B-cell lymphoma and its clinical significance
10.3760/cma.j.issn.1009-9921.2017.04.005
- VernacularTitle:弥漫大B细胞淋巴瘤外周血CD13+CD4+CD25hi调节性T细胞的表达及其临床意义
- Author:
Xin LYU
;
Shibing CHEN
;
Qian ZHOU
;
Shibin YAN
;
Meiying FAN
;
Hongxia QIU
- Keywords:
Lymphoma;
large B-cell;
diffuse;
T lymphocytes;
regulatory;
Prognosis;
Clinical stage
- From:
Journal of Leukemia & Lymphoma
2017;26(4):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of peripheral blood CD13+CD4+CD25hi regulatory T cells (Treg cells) in patients with diffuse large B-cell lymphoma (DLBCL) and its clinical significance. Methods The expression of peripheral blood CD13+CD4+CD25hi Treg cells in 58 newly diagnosed patients with DLBCL and 30 healthy adults was detected by flow cytometry, and the relationship between its expression and the clinical indicators were analyzed statistically. Results The levels of peripheral blood CD13+CD4+CD25hi Treg cells in newly diagnosed DLBCL and healthy adults were different, with statistically significant difference [(36.37 ±11.89) % vs. (9.03 ±2.10) %, t = 7.168, P < 0.001]. The level of peripheral blood CD13+CD4+CD25hi Treg cells was significantly higher in patients with IPI score 3ˉ5 than that in patients with IPI score 0ˉ2[(44.28±10.10)%vs. (21.51±6.23)%, t=ˉ9.347, P=0.03]. The expression of peripheral blood CD13+ CD4+ CD25hi Treg cells in stages Ⅱ, Ⅲ and Ⅳ patients were (19.48 ±1.34) %, (33.98 ±8.03) % and (47.89±8.25) %respectively, and there were significant differences among three groups (F= 38.363, P<0.001). The levels of peripheral blood CD13+CD4+CD25hi Treg cells had no relationship with age, sex or LDH level (all P>0.05). Conclusion The levels of peripheral blood CD13+CD4+CD25hi Treg cells are higher in DLBCL patients, which has a close relationship between the expression of CD13+CD4+CD25hi Treg cells and clinical stage and prognosis.
