Progress of next generation sequencing in activated B-cell like diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2017.04.017
- VernacularTitle:二代测序在活化B细胞样弥漫大B细胞淋巴瘤中的研究进展
- Author:
Wenjing DUAN
- Keywords:
Lymphoma;
large B-cell;
diffuse;
Genes;
Molecular targeted therapy
- From:
Journal of Leukemia & Lymphoma
2017;26(4):249-252
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse large B-cell lymphoma (DLBCL), being the most common lymphoma entity, accounting for 30 % ˉ 40 % of newly diagnosed non-Hodgkin lymphomas, is a kind of highly heterogeneous lymphoma with different pathogenesis, clinical manifestations, morphological characteristics, the immune phenotype, molecular subgroup and clinical outcomes. Gene sequencing of DLBCL has redefined the genetic landscape of the disease by identifying recurrent single nucleotide variants, which provides more powerful evidence to support accurate diagnosis and targeted treatment in DLBCL molecular subtypes.
