Diuretic efficacy of torasemide in nephrotic syndrome: bolus injection versus continuous infusion
10.3760/cma.j.issn.1001-7097.2017.02.001
- VernacularTitle:肾病综合征患者使用托拉塞米恒速泵持续静脉滴注与静脉注射的利尿效果比较
- Author:
Jing LI
;
Jianteng XIE
;
Xipei WANG
;
Huizhen WANG
;
Yangyang ZUO
;
Sheng LI
;
Menglei JU
;
Lei FU
;
Feng WEN
;
Wei SHI
;
Wenjian WANG
- Keywords:
Nephrotic syndrome;
Diuretics;
Edema;
Torasemide;
Albuminuria
- From:
Chinese Journal of Nephrology
2017;33(2):81-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the diuretic efficacy of torasemide as a 2-hour continuous infusion and as a bolus injection of equal dose in patients with nephrotic syndrome,and to investigate a preferable administration mode of torasemide for these patients.Methods Twenty-three hospitalized patients were randomized to receive torasemide 20 mg or 40 mg per day by either 2-hour intravenous infusion or bolus injection,and interchanged after 48 hours of washout.Results Patients received torasemide by 2-hour intravenous infusion exhibited significantly higher daily urinary volume,chloride excretion,sodium excretion and fractional excretion of sodium (FENa) within 24 hours than those by bolus injection (P ＜ 0.05).Significantly lower bound-state torasemide excretion,higher ratio of urinary volume to torasemide excretion and a markedly larger area under the curve in the plasma concentrationtime profiles were also observed in the infusion group (P ＜ 0.05).Conclusion 2-hour continuous infusion delivers a better diuretic effect compared with a bolus injection of equal dose of torasemide in patients with nephrotic syndrome.
