Literature Analysis of ADR Induced by Dasatinib

VernacularTitle:达沙替尼致不良反应文献分析
Author: Jianhong ZHANG ; Ziyan LIU ; Hongna HUANG ; Danli TIAN ; Liqin ZHU
Keywords: Dasatinib; ADR; Literature analysis
From: China Pharmacy 2017;28(11):1493-1495
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To investigate ADR induced by dasatinib,and to provide reference for clinical rational drug use. METHODS:By means of literature metrology method,dasatinib-induced ADR cases domestically and internationally reported were analyzed. RSEULTS:A total of 63 ADR cases were induced by dasatinib,and the age of patients were mainly 41-60 years old. The most cases(25.4%)occurred within 1 month of medication. The patients mainly were from Asian countries and regions(53.9%). Organs/systems involved in dasatinib induced ADRs were mainly respiratory system(40.1%),digestive system(17.5%)and hema-tologic system(11.7%). Main clinical manifestations were pleural effusion(23 cases),pulmonary artery hypertension(15 cases), expiratory dyspnea(8 cases),diarrhea(8 cases),etc. CONCLUSIONS:Daring the use of dasatinib,great importance should be attached to ADR monitoring and prevention so as to avoid serious ADR.