Clinical Observation of Levetiracetam Add-on Therapy in the Treatment of Elderly Epileptic Patients
10.6039/j.issn.1001-0408.2017.11.22
- VernacularTitle:左乙拉西坦添加治疗老年癫痫患者的临床观察
- Author:
Ling WAN
;
Hua LEI
- Keywords:
Levetiracetam;
Elderly patient;
Epilepsy;
Coma;
Daily living ability;
Cognitive function
- From:
China Pharmacy
2017;28(11):1516-1518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate clinical efficacy and safety of levetiracetam add-on therapy in the treatment of elderly epileptic patients. METHODS:Totally 88 elderly epileptic patients in Chongqing Yunyang County Hospital of TCM during Jan. 2014-Jan. 2016 were divided into observation group and control group according to random number table,with 44 cases in each group. Control group was given routine antiepileptic therapy of carbamazepine+phenobarbital;observation group was additionally given Levetiracetam tablet with initial dose of 0.25g,increasing to 0.5 g according to disease condition,bid,on the basis of con-trol group. Treatment courses of 2 groups lasted for 6 months. Clinical efficacies,GCS score,Barthel index score,MoCA score and the occurrence of ADR were observed in 2 groups. RESULTS:Total response rate,control rate and MoCA score of observation group were significantly higher than those of control group,with statistical significance(P<0.05). GCS and Barthel index score of 2 group after treatment were significantly higher than before treatment,and those 2 scores of observation group were significantly higher than those of control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLU-SIONS:Levetiracetam add-on therapy is better than routine therapy plan in the treatment of elderly epilepsy,and significantly re-duce coma degree,increase daily living ability and cognitive function with good safety.
