Research advances on circulating miRNAs in esophageal cancer
10.3760/cma.j.issn.1001-4497.2017.02.019
- VernacularTitle:循环miRNA与食管癌诊断和预后的研究进展
- Author:
Yibo SHAN
;
Hongcan SHI
;
Zhengwen LEI
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2017;33(2):126-128
- CountryChina
- Language:Chinese
-
Abstract:
There is a high incidence of esophageal cancer(EC) in China.The survival and prognosis of EC is unoptimistic due to the lack of efficient early diagnostic markers.There is an urgent demand of novel biomarkers with more stability,sensitivity and specificity.miRNAs are a class of small non-coding single stranded RNAs consisting of 21-23 nucleotides,which are involved in the pathological and physiological process of life activities.miRNAs are stable not only in tumor tissues,but also in serum/plasma.There are significant differences in the expression patterns of circulating miRNAs between two main types of EC.They are closely related to the occurrence and progression of EC,which make circulating miRNAs a novel kind of biomarkers for differential diagnosis,early supervision of esophageal cancer,and prognosis.
