Roles of microglia in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2017.01.012
- VernacularTitle:小胶质细胞在脑缺血中的作用
- Author:
Wenqian WU
;
Heng XU
;
Shoucai ZHAO
;
Fudong LIU
- Keywords:
Brain Ischemia;
Microglia;
Inflammation;
Cell Polarity;
Phenotype;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2017;25(1):91-94
- CountryChina
- Language:Chinese
-
Abstract:
Microglia play a crucial role in inflammation after cerebral ischemia.A large number of studies have shown that microglia are highly plastic cells that can assume different phenotypes and functions in response to specific microenvironmental signals.Microglia can be polarized into the classically activated proinflammatory M1 phenotype or the alternatively activated anti-inflammatory M2 phenotype,and play different roles in ischemic injury.Irnhibiting M1 while stimulating M2 may be a new approach for the treatment of ischemic stroke.
