Research progress of idiopathic membranous nephropathy associated antigen phospholipase A2 receptor and thrombospondin type-1 domain containing 7A
10.3760/cma.j.issn.1008-6315.2017.03.022
- VernacularTitle:特发性膜性肾病相关抗原M型磷脂酶A2受体和1型血小板反应蛋白7A域的研究进展
- Author:
Yanhong GUO
;
Danxia ZHENG
;
Yue WANG
- Keywords:
Idiopathic membranous nephropathy;
Phospholipase A2 receptor;
Thrombospondin Type-1 Domain containing 7A
- From:
Clinical Medicine of China
2017;33(3):280-285
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic membranous nephropathy(IMN) is one of the main pathology of nephrotic syndrome,and has a rising trend year by year.In recent years that IMN is organ specific autoimmune disease.Phospholipase A2 receptor(PLA2R) and thrombospondin type-1 domain containing 7A(THSD7A) are the two main antigens of IMN,which could be used to distinguish the IMN and secondary membranous nephropathy.The anti-PLA2R antibody and anti-THSD7A antibody are associated with diagnosis,severity and activity of the disease.The antibody titer and its change could be used to help deciding the beginning of therapy and the therapitive courses.
