Pharmacokinetics of Indometacin Enteric-coated Dropping Pills in Beagle Dogs
- VernacularTitle:吲哚美辛肠溶滴丸在比格犬体内的药动学研究
- Author:
Jun WANG
;
Xiaohua FANG
;
Yongjun HU
- Keywords:
Indometacin;
Enteric-coated dropping pills;
Enteric-coated tablets;
Pharmacokinetics;
Beagle dogs
- From:
China Pharmacist
2017;20(4):655-657
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the pharmacokinetics of indometacin (IDM) enteric-coated dropping pills.Methods:Beagle dogs were used as the experimental animals and the marketed IDM enteric-coated tablets were applied as the control,the pharmacokinetics of IDM enteric-coated dropping pills was studied after a single oral administration.DAS software was used for the model fit and parameter calculation,and the bioequivalence was also evaluated.Results:Both IDM enteric-coated dropping pills and tablets were fitted a one-compartment model.Compared with those of IDM enteric-coated tablets,the Cmax,Tmax,AUC0-∞and Tlag of IDM enteric-coated dropping pills all showed notable differences (P<0.05),and the former two increased significantly,and the latter two were shortened significantly.The relative bioavailability of the dropping pills was (121.0±7.7)%.Conclusion:Compared with IDM enteric-coated tablets,IDM enteric-coated dropping pills are with significantly enhanced absorption and shortened lag time,which is worthy of further studies and development.
