Expression of PcG related protein RYBP in pancreatic carcinoma and its clinical significance

VernacularTitle:胰腺癌中PcG相关蛋白RYBP的表达及临床意义
Author: Wei LUO ; Xiaonian ZHU ; Shengkui TAN
Keywords: pancreatic neoplasms; RYBP; cell apoptosis
From: Chinese Journal of Clinical and Experimental Pathology 2017;33(2):125-128
CountryChina
Language:Chinese
Abstract: Purpose To investigate the expression and clinical significance of RINGI and YYI binding protein (RYBP)in pancreatic carcinoma (PC).Methods RYBP expression was detected in 51 cases of PC tissues and paired adjacent nontumor tissues by immunohistochemistry.The correlation between RYBP expression and the survival time of PC patients after surgery was analyzed by Kaplan-Meier method.Results Compared to the expression in adjacent non-tumor tissues,RYBP was significantly lower expressed in PC tissues (P ＜ 0.05).In addition,RYBP expression had a significant correlation with tumor diameter and tumor staging of patients (P ＜ 0.05),but no significant correlation with other characteristics of patients,such as gender,age,smoking,alcohol intake,tumor number,metastasis or CA199 level (P ＞ 0.05).The survival analysis showed that the survival time of PC patients with positive expression of RYBP was significantly longer than patients with negative expression of RYBP (P ＜ 0.05).Conclusion RYBP is significantly lower expressed in PC tissues,which might be involved in the pathogenesis of PC.