Role of cannabinoid receptor Ⅰ-mediated synaptic plasticity in neuropathic pain and associated depression

VernacularTitle:大麻素受体Ⅰ介导的突触可塑性在神经病理性疼痛及其所致抑郁中的作用
Author: Wei PAN ; Xingming WANG ; Guangfen ZHANG ; Jianjun YANG
Keywords: cannabinoid receptor 1; neuropathic pain; depression; synaptic plasticity
From: Journal of Central South University(Medical Sciences) 2017;42(3):340-345
CountryChina
Language:Chinese
Abstract: Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system and characterized by spontaneous pain,allodynia,and hyperalgesia.It is well established that central sensitization is one of the key mechanisms underlying the development and maintenance of neuropathic pain.Cannabinoid receptor 1 (CB1R) of endocannabinoid system modulates synaptic transmission,regulates synaptic plasticity,inhibits central sensitization,and thus attenuates neuropathic pain.Recent studies have shown that activation of CB1R also involves in the relief of neuropathic pain-induced depression.