Research progress in vasculogenic mimicry in multiple tumors
10.11817/j.issn.1672-7347.2017.03.020
- VernacularTitle:血管形成拟态在肿瘤中的研究进展
- Author:
Ju BAI
;
Zhijie XU
;
Chaoliang LIAO
;
Lifang YANG
- Keywords:
vasculogenic mimicry;
cancer;
signal pathways;
therapy
- From:
Journal of Central South University(Medical Sciences)
2017;42(3):357-364
- CountryChina
- Language:Chinese
-
Abstract:
Vasculogenic mimicry (VM) is a brand-new tumor vascular pattern with the ability to form vessellike networks without participation of endothelial cells and independent on angiogenesis.It can provide adequate blood supply for tumor growth.The formation of VM involves multiple molecule mechanisms and signal pathways,including cancer stem cell and epithelial-mesenchymal transition.As a unique blood-supply pattern,VM is associated with cancer invasion,metastasis and poor prognosis.Because of its important role in cancer progression,VM will become a new target for therapy of cancers.
