Diagnostic Value and Significance of the HLA-DR53,Anti-Sa and Anti-CCP Antibody Factors Combination in Rheumatoid Arthritis
10.3969/j.issn.1671-7414.2017.02.021
- VernacularTitle:HLA-DR53,anti-Sa和anti-CCP抗体联合检测对诊断类风湿关节炎的临床应用价值
- Author:
Na ZHAO
;
Xingning WANG
;
Liangyong JIA
- Keywords:
Rheumatoid arthritis(RA);
HLA-DR53;
anti Sa antibody;
anti-CCP antibody
- From:
Journal of Modern Laboratory Medicine
2017;32(2):78-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of human leucocyte antigen-DR53 (HLA-DR53),anti-Sa antibody and anti-cyclic citrullinated peptide antibody(anti-CCP) factors combination in rheumatoid arthritis.Methods 170 patients with rheumatoid arthritis and 50 healthy individuals in the hospital were chosen.The levels of HLA-DR53 by PCR-SSP,the levels of anti-Sa and anti-CCP by ELISA,compared their diagnostic value by consistency analysis and joint detection analysis.Results The sensibility of anti-Sa,HLA-DR53 and anti-CCP in RA were 44.07% (P =0.00,x2 =165.214),68.65 % (P =0.00,x2 =9.837) and 79.45 % (P=0.00,x2=48.028).Consistency analysis in RA,HLA DR53,anti-CCP and anti-Sa highly consistent,OR were 3.94,38.6 and 184.52.The sensitivity and Youden index of anti-CCP were the highest.The sensitivity of anti Sa and anti-CCP parallelled was 88.51 %.The sensitivity of HLA-DR53 and anti-CCP parallelled was 93.56%,and the spe cificity of anti-Sa and anti-CCP of RA were 100%.Conclusion There is a certain correlation between HLA-DR53,anti-Sa and anti-CCP antibody,which are related risk factors of RA,co-detection will improve the diagnosis of RA.