Research progress on the virulence factors of Streptococcus hemolysin S
10.3969/j.issn.1002-2694.2017.03.018
- VernacularTitle:链球菌毒力因子溶血素S的研究进展
- Author:
Hong WANG
;
Shuang PENG
;
Defang CHEN
- Keywords:
Streptococcus pyogenes;
streptolysin S;
structure;
pathogenic function
- From:
Chinese Journal of Zoonoses
2017;33(3):287-292
- CountryChina
- Language:Chinese
-
Abstract:
Streptolysin S (SLS),one of the important virulence factors of Streptococcus,exist in several kinds of human and animal pathogenic bacterial,including Streptococcus pyogenes,Strepstococcus iniae and Streptococcus anginosus.SLS is a peptide toxin encoded by nine consecutive genes (sagA-sagⅠ).The functions of SLS include contributing pathogenic bacterium to pass through epithelial barrier,causing tissue damage,resisting to phagocytic clearance of host immune cells and interacting with other virulence factors.In addition,SLS as a signaling molecule of cell quorum sensing is involved in regulating the expression with other virulence factors.This paper summarized the structures and the biological functions of SLS in Streptococcus infection.
