Clinical Significance of Serum Bun,Cr,Cys C and RBP Combined Detection for Early Diagnosis of Renal Damage in Patients with Lupus Nephritis
10.3969/j.issn.1671-7414.2017.02.031
- VernacularTitle:血清四项生化指标联合检测在狼疮肾炎患者早期肾损伤的临床意义
- Author:
Na ZHU
;
Lixia ZHANG
;
Hua ZHANG
;
Fengyu XI
;
Ting FENG
- Keywords:
lupus nephritis;
urea nitrogen;
creatinine;
urinary inhibition C;
retinol binding protein;
combined detection
- From:
Journal of Modern Laboratory Medicine
2017;32(2):114-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the serum urea nitrogen (BUN),creatinine (Cr),urinary inhibition C (CysC) and retinol binding protein (RBP) four biochemical indicators of joint detection on the early diagnostic value of lupus nephritis (LN).Methods According to the American Rheumatology Association (ACR) 2012 revision of the diagnostic criteria,collected 177 LN patients with kidney disease from January 2011 to April 2016 in Shaanxi Provincial People's Hospital,at the same time,choose 167 cases of healthy physical examination as normal control group.With Hitachi 7170A a fully automated analy zer on two groups of serum BUN,Cr,CysC and concentration of RBP for testing,the data obtained by SPSS17.0 statistical software for statistical analysis.Results LN patient group compared with healthy controls,the serum BUN (6.67 ± 1.43 mmol/L vs 6.57±1.16 mmol/L),Cr (96.9±10.1 μmol/L vs 92.6±13.2 μmol/L),CysC (1.7±0.5 mg/L vs 0.75±0.15 mg/L),RBP (180.5±8.28 mg/L vs 42.6±9.6 mg/L) concentrations were higher,and serum CysC,RBP higher level com pared with healthy control group difference was statistically significant (t=8.145,21.594,all P＜0.05).Single parameter detected abnormal rate in terms of LN patients serum BUN,Cr,CysC and RBP abnormal rates were 28.3％,29.4％,68.4 ％,65.0 ％,four indicators combined detection of abnormal rate was 85.3 ％,significantly higher than the single parameter test (x2 =35.973～168.742,all P＜0.01).Conclusion Conbined detection of BUN,Cr,CysC and RBP four early diagnosis of renal damage in patients with lupus nephritis had important clinical value.
