Investigation to the Expression of NE and TNF-α in Serum and BALF of Rabbits with Acute Lung Injury Interposed by XueBiJing in Underwater Explosion
10.3969/j.issn.1671-7414.2017.02.033
- VernacularTitle:血必净干预对水下爆炸致兔急性肺损伤血清和支气管肺泡灌洗液NE,TNF-α表达的影响
- Author:
Xueping LI
;
Xiaolin QI
;
Changqing YE
;
Qianjin WANG
;
Xianan SHAO
;
Honghao MA
- Keywords:
Underwater explosion;
acute lung injury;
XueBiJing;
tumor necrosis factor-alpha;
neutrophil elastase
- From:
Journal of Modern Laboratory Medicine
2017;32(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective The concentration of NE and TNF-α was detected for elucidating the change of them in sera and bronchoalveolar lavage fluid (BALF) of rabbits with acute lung injury interposed by XueBiJing therapy in underwater explosion.Methods Underwater explosion decive was applied to cause acute lung injury of rabbits.The 20 rabbits were randomly divided into two groups which were injury group and XueBiJing therapy group,respectively.The concentration of NE and TNF-α in sera and BALF were detected by ELISA method in 24 hours after bursting.Results The concentration of TNF-α in sera (353.30±166.86 ng/L) of rabbits in therapy group were significantly lower than those in injury group (552.30± 169.64 ng/L;t=2.645,P =0.016).The concentration of NE in sera (63.40 ± 36.09 ng/ml) were lower than that of rabbits in injury group (97.60 ± 36.20 ng/ml;t=2.116,P=0.049).At the same time the concentration of NE in BALF (102.10± 9.50 ng/ml) of rabbits in therapy group were significantly lower than those in injury group (136.70± 13.60 ng/ml;t=6.593,P=0.000).Conclusion The expression of TNF-α in sera and NE in sera and BALF in rabbits with acute lung injury interposed by XueBiJing in underwater explosion were lower than those of injury group.
