Expression of c-myc and MDM2 protein in multiple myeloma and their clinical significance
10.13315/j.cnki.cjcep.2017.02.011
- VernacularTitle:多发性骨髓瘤中c-myc和MDM2蛋白的表达及其临床意义
- Author:
Zhihua ZHAO
;
Yan TIAN
;
Kuisheng CHEN
- Keywords:
bone neoplasms;
multiple myeloma;
c-myc protein;
MDM2 protein;
clinical stage
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(2):165-168
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of c-myc and MDM2 protein in multiple myeloma (MM) and their correlation with clinical stage.Methods Immunohistochemical SP three-step method was used to detect the expression of MDM2 and c-myc protein in 60 cases of MM with different clinical stages and 10 cases of nontumorous bone marrow tissue.Results The positive rate of c-myc protein in MM and nontumorous bone marrow tissue were 71.7％ and 10.0％;the positive rate of MDM2 protein in two tissues were 80.0％ and 20.0％,respectively.The expression difference of two proteins between MM and nontumorous bone marrow tissue was statistically significant (P ＜ 0.05).The expression of c-myc and MDM2 protein was positively correlated with MM clinical ISS stage (P ＜ 0.05),but irrelevant with the age and gender.The expression of c-myc and MDM2 protein in MM was positively correlated (P ＜ 0.05).Conclusion The c-myc and MDM2 protein have a highly expression in MM,and it may be relative to the occurrence of MM and clinical stage.In the MM,c-myc and MDM2 protein may have synergetic functions and promote the development of tumor.
