Expression of RET gene in cervical squamous cell carcinoma
10.3969/j.issn.1006-5725.2017.06.014
- VernacularTitle:RET基因在宫颈鳞癌中的表达及与预后的关系
- Author:
Huaying LI
;
Jianchao DENG
;
Shouguo HUANG
- Keywords:
Cervical squamous cell carcinoma;
RET;
Survival analysis;
Prognosis
- From:
The Journal of Practical Medicine
2017;33(6):901-904
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of RET in cervical squamous carcinoma tissues and evaluate its relationship with cervical squamous carcinoma clinical pathological indexes and its prognostic value. Methods The expression and distribution of RET in normal cervical tissues ,CINⅠ,CINⅡ& CINⅢ and cervical squamous carcinomas tissues were detected by immunohistochemistry in wax blocks. Clinical data and follow-up data are integrated to analyze its relationship with clinical pathological factors and prognosis value. Results The positive rate of RET protein in cervical squamous carcinomas tissues is higher than in other tissues.The positive rate was related to FIGO stage and lymph node metastasis(P<0.05),and not related with the age of patients or the degree of tumor differentiation(P>0.05). The result of survival analysis with Kaplan-Meier method showed poorer disease-free survival time in the patients with high expression of RET (P < 0.05). Prognostic analysis of patients with cervical cancer through COX proportional hazard regression model suggested that RET expression was an independent prognostic factor. Conclusions RET has been involved in the progression ,FIGO stage and metastasis of cervical squamous cell carcinomas.
