Expression of Stat5 in thyroid carcinoma and its relationship with EMT
10.3969/j.issn.1006-5725.2017.06.015
- VernacularTitle:Stat5在甲状腺癌中的表达及其与上皮间质转化的关系
- Author:
Yun XUE
;
Daoming LI
;
Jing ZHANG
;
Pei HUANG
;
Yuhui YIN
- Keywords:
Thyroid neoplasm;
Signal transducers and activators of transcription 5;
Epithelial mesen-chymal transition;
E-cadherin;
Vimentin
- From:
The Journal of Practical Medicine
2017;33(6):905-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Stat5,E-cadherin and Vimentin in thyroid carcinoma and the correlation among them. Method The expression of Stat5,E-cadherin and Vimentin in 149 cases of thyroid specimens(including 23 cases of nodular goiter and 126 cases of thyroid carcinoma)was detected by immunohisto-chemistry SP method and the correlation analysis was conducted with the main clinical pathological parameters. Results The positive rate of Stat5 and Vimentin in thyroid carcinoma was 85.71% and 77.78% respectively, which was significantly higher than that in nodular goiter(26.09%and 8.70%)(P<0.05)and the positive rate of E-cadherin in thyroid carcinoma was 25.40%,lower than that in nodular goiter(86.96%)(P<0.05). Three kinds of protein expression were not significantly correlated with gender and age (P > 0.05),but obviously with lymph node metastasis and pathological type(P<0.05). Stat5 was negatively correlated with the expression of E-cadherin (r=-0.335,P=0.000)but positively with the expression of Vimentin(r=0.218,P<0.05). Conclusion The high expression of Stat5 and EMT in thyroid carcinoma tissues indicate that Stat5 may be involved in the EMT process of thyroid carcinoma ,thus it can promote the invasion and metastasis of thyroid carcinoma.
