Combination therapy with milrinone and esmolol in patients with septic myocardial depression
10.3969/j.issn.1006-5725.2017.06.033
- VernacularTitle:脓毒症心肌抑制患者静脉泵入米力农联合艾司洛尔的短期疗效
- Author:
Suping NIU
;
Wei CHEN
;
Xuefeng ZANG
;
Lei ZHAO
;
Bo SHENG
;
Jie ZHEN
;
Weishuai BIAN
- Keywords:
Sepsis;
myocardial depression;
Milrinone;
Esmolol
- From:
The Journal of Practical Medicine
2017;33(6):971-975
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of combination therapy with milrinone and esmolol on hemodynamics and cardiac function in patients with septic myocardial depression. Methods From October 2010 to October 2013,after the hemodynamics and cardiac function were evaluated by pulse indicator continuous cardiac output (PICCO),74 sepsispatients withCI < 2.2 L/min · m2 after fluid resuscitation were enrolled in the study and were divided into group A with intravenous injection of dobutamine hydrochloride ,and group B with intravenous injection of milrinone and esmolol,with 37 cases in each group. The patients'PICCO indicators, echocardiography and cardiac biomarker(CK,CK-MB,MYO,cTnI and ProBNP)in two groups were compared before and after 3-day treatment. Results (1)CI and GEF were significantly increased in group B after 3-day treatment when compared with those in group A.(2)Compared with those in group A,early diastolic mitral flow velocity/end diastolic mitral velocity (E/A) and right ventricular diastolic diameter(RVD) in group B had statistical significance.(3) CK-MB,cTnI and ProBNP decreased significantly in group B when compared with those in group A. Conclusion Combination therapy with milrinone and esmolol can increase cardiac ejection function,slow down the heart rate,reduce the heart blood and vascular preload,lessen the injury of myocardial and improve heart function.
