Clinical effect ofJiedu-Huayu granule for the degnue fever

VernacularTitle:解毒化瘀颗粒结合西医常规疗法治疗登革热临床研究
Author: Luping LIN ; Lingdi LIU ; Jiao LIU ; Lingzhai ZHAO ; Fuchun ZHANG ; Xinghua TAN
Keywords: Dengue; Cytokines; Jiedu-Huayu granule; Integrated Chinese traditional and western medicine therapy
From: International Journal of Traditional Chinese Medicine 2017;39(5):402-407
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical effect ofJiedu-Huayu granule for the Dengue Fever (DF).Methods The patients with DF were randomly divided into the treatment group and control group. Both groups received the conventional treatment, and the treatment group addedJiedu-Huayu granule. The clinical effects were detected.Results At the baseline, the ALT and AST in the treatment were significantly higher than those in the control group (t=2.830,P=0.014;t=2.109,P=0.044). But after treatment, there was no difference between groups. The ALT in the treatment group showed a gradual change and AST recovery time showed short. Compared with control group, the concentration of sVCAM-1 in the treatment group was higher at baseline and the third day (t=2.780,P=0.018;t=2.130,P=0.460), but the concentration of MCP-1 desceased significantly on the 6th day (t=-2.164,P=0.042).Conclusions Compared with the western medicine, the treatment of western medicine andJiedu-Huayu granule could alleviate liver injure, shorten the recovery time, and reduce the concentration of sVCAM-1 and MCP-1.