Meta-analysis on the randomized controlled trials of breviscapine injection plus conventional therapy for unstable angina pectoris
10.3760/cma.j.issn.1673-4246.2017.05.010
- VernacularTitle:基于meta分析的灯盏花素注射液治疗不稳定型心绞痛临床评价研究
- Author:
Dan ZHANG
;
Jie LI
;
Jiarui WU
;
Bing ZHANG
- Keywords:
Angina;
unstable;
Randomized controlled trials;
Meta-analysis;
Breviscapine injection
- From:
International Journal of Traditional Chinese Medicine
2017;39(5):424-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the clinical effectiveness and safety of Breviscapine injection combined with conventional therapy in the treatment of unstable angina pectoris (UAP).Methods The literature were systematicly retrieved about the randomized controlled trials (RCTs) of Breviscapine injection for UAP. The Cochrane Risk of Bias Assessment Table was used to evaluate the methodological quality of the RCTs and then the data were extracted and meta-analysed by RevMan 5.3 software.Results A total of 15 RCTs with 1202 participants were included. In the meta-analysis, the combination of Breviscapine injection and conventional therapy in the treatment of UAP can achieve better angina pectoris curative effect (Z=7.74,P<0.01), theRR(95% CI) was 1.23 (1.17,1.30), and the electrocardiogram curative effect (Z=6.26,P<0.01), the RR(95% CI) was 1.32(1.21, 1.44). Furthermore, Breviscapine injection can improve hemorheologic parameters. And there was no major or serious adverse drug event.Conclusions The Breviscapine injection combined with conventional therapy shows good therapeutic effect on UAP.
