A study of association of soluble lectin?like oxidized low?density lipoprotein receptor?1 and leptin with metabolic syndrome

VernacularTitle:sLOX?1和瘦素水平与代谢综合征的相关性
Author: Yujing DING ; Lijun QIU ; Chen XU ; Weidong SU
Keywords: sLOX?1; Leptin; Metabolic Syndrome
From: The Journal of Practical Medicine 2017;33(5):813-815
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of sLOX?1 and leptin in metabolic syndrome ,glucose and lipid metabolism. Methods 58 patients with metabolic syndrome were included in the study ,with other 35 normal controls as control group. Fasting venous blood samples were collected. ELISA method was used to detect serum sLOX?1 and leptin levels. The related biochemical indicators were tested. Results The sLOX?1 and leptin levels in the metabolic syndrome group were significantly higher than those in the control group(P < 0.01). The levels of sLOX?1 and leptin were further compared between different genders. The differences were not statistically significant (P > 0.05). sLOX?1 and leptin levels were positively correlated. They were positively correlated with WAIST,TG,SBP,DBP,and negatively correlated with HDL?C. Leptin and age,FPG also had positive correlation,but sLOX?1 was not correlated with age and FPG. Conclusion sLOX?1 may be able to predict endothelial damage in patients with metabolic syndrome in an early stage. Combined with leptin ,the endothelial dysfunction could be reflected more accurately. They may be the important factors for early diagnosis and risk assessment of metabolic syndrome.