Glucolipid Metabolic Disease and Precision Medicine
10.11842/wst.2017.01.007
- VernacularTitle:糖脂代谢病与精准医学
- Author:
Jiao GUO
;
Xue XIAO
;
Xianglu RONG
;
Dewei YE
;
Shikai YAN
- Keywords:
Glucolipid metabolic disease;
disorder of glucose metabolism;
disorder of lipid metabolism;
precision medicine
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Diseases of glucose and lipid metabolism disorder,presented rather complicated pathological mechanism,often with clinical pattern of multiple concurrent diseases.Therefore,the traditional single-disease based on treatment methods need improving.In view of plenty of clinical practice,theatrical and fundamental researches,the pathological mechanisms of some chronic disorders,such as hyperlipidemia,nonalcoholic fatty liver disease,type 2 diabetes,hypertension,atherosclerosis and severe cardiovascular complications,resulted from the impairment in the metabolism of glucose and lipid were investigated using the method of integrated Chinese and western medicine.Overall,the features of these diseases and their common characteristics were discovered,and accordingly we defined the new concept of glucolipid metabolic disease (GLMD) and put forward the concept of pivot liver of metabolic regulation system.In addition,we developed the therapeutic strategy of modulating liver,starting pivot and cleaning turbidity,for the comprehensive and integrated treatment and prevention of these diseases.The theory of GLMD shared the critical characteristics with precision medicine,taking its own specialty.Finally,the content and approaches for the research of GLMD were proposed,and some essential and core fields in the precision medical research for GLMD were profoundly analyzed and prospected.
