Effects of Qi Kui Granules on Urine Protein and Inflammatory Markers in Patients with Type 2 Diabetic Nephropathy
10.11842/wst.2017.01.022
- VernacularTitle:芪葵颗粒对2型糖尿病肾病患者蛋白尿及炎症因子的影响
- Author:
Shaofeng XIE
;
Wen CAO
;
Yongxin HU
;
Xiaoqiu ZHU
;
Boyu ZHU
;
Jiangyi YU
;
Liji HUANG
- Keywords:
Diabetic nephropathy;
Qi Kui granules;
proteinuria;
inflammatory cytokine;
transforming growth factor β1;
monocyte chemoattractant protein-1
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(1):149-153
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed at investigating the effects of Chinese herbal compound Qi Kui granules on urine protein and inflammatory markers in patients with type 2 diabetic nephropathy (DN) based on the treatment of regular western medication.A randomized,parallel controlled method was involved in the present trial,and patients diagnosed with type 2 DN were randomly divided into the Chinese herb group and the control group.Regular treatment of angiotensin Ⅱ receptor blocker (ARB) in western medicine was administered in the two groups with the additional treatment of Qi Kui granules for the Chinese herb group.All the patients revisited the doctor every 4 weeks during the observation period within a 12-week course of the observation.Urinary albumin to creatinine ratio (UACR),urinary albumin excretion rate (UAER) and inflammatory cytokines in the two groups were determined.As a result,seventy-two patients in aggregate were included in the study,while 32 patients of the control group and 31 patients of the Chinese herb group effectively accomplished the observation.After the 12-week treatments,UACR and UAER were significantly decreased in the two groups (P ＜ 0.01),while the efficacy of the Chinese herb group was better than that of the control group (P ＜ 0.05).Compared with the control group,the levels of serum IL-6,tumor necrosis factor α (TNF-α),transforming growth factor f1 (TGF-f1) and urinary monocyte chemoattractant protein (MCP-1) / Cr significantly decreased after the 12-week treatment (P ＜ 0.01).It was concluded that the Chinese herbal compound Qi Kui granules successfully mitigated proteinuria in DN patients.The improvement of glomerular inflammation for renoprotection should be the mechanism behind this.
