HP1γ promotes the development of ovarian cancer and is modulated by miR-30b
10.3969/j.issn.1006-5725.2017.06.012
- VernacularTitle:异染色质相关蛋白1γ促进卵巢癌的进展并受微小RNA-30b的调控
- Author:
Dan YE
;
Wei DU
;
Jing LIANG
- Keywords:
Ovarian Cancer;
HP1γ;
Mir-30b;
Cell proliferation
- From:
The Journal of Practical Medicine
2017;33(6):895-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of HP1γ on the development of ovarian cancer. Methods RT-qPCR was used to deteched the level of HP1γin ovarian cancer samples. The proliferation of A2780 and SKOV3 cell line was detected by CCK8 assay. RNAi was used to knock down the expression of HP1γ mRNA. Results The level of HP1γwas higher in ovarian cancer than that in the normal tissue. Mir-30b may inhibit the proliferation of ovarian cancer cell. Conclusion HP1γpromotes the proliferation and progress of ovarian cancer cells.
