The relationship of CYP2C19 gene polymorphism with clopidogrel responsiveness and the level of EETs in patients with acute coronary syndrome
10.3969/j.issn.1006-5725.2017.06.017
- VernacularTitle:急性冠脉综合征患者CYP2C19基因多态性与氯吡格雷反应性及与血浆EETs的相关性
- Author:
Houming LI
;
Yanxian FENG
;
Yuli HUANG
;
Miaonan LI
;
Hongju WANG
- Keywords:
Acute coronary syndrome;
Low clopidogrel responsiveness;
Thromboelastography;
CYP2C19;
EETs
- From:
The Journal of Practical Medicine
2017;33(6):912-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the relationship of CYP2C19 gene polymorphism with clopidogrel respon-siveness and the level of EETs in patients with ACS. Methods A total of 123 patients with ACS receiving aspirin combined with clopidogrel dual antiplatelet were enrolled. According to the results of CYP2C19 genotype,patients were divided into three groups:fast metabolic type ,medium metabolic type ,and slow metabolism type. The concentration of EETs and PAIR were compared between three groups. Logistic analysis was used to analyze the risk factors of LCR. Results There were differences statistically in level of EETs and PAIR among the three groups(P<0.05). Logistic analysis showed that the slow metabolism of CYP2C19 gene and lower EETs level were risk factors for LCR. The area under the ROC curve was 0.893(P < 0.05)by EETs level to predict the CYP2C19 genotype. Conclusion The slow metabolism of CYP2C19 gene was an independent risk factor for LCR,while the increase of plasma EETs level was a protective factor.
