Influence of atoxiban on pregnancy outcome in patients with repeated implantion failure in Blastcyst Thawed Embryo Transfer

VernacularTitle:阿托西班对反复着床失败后冻融周期囊胚移植妊娠结局的影响
Author: Jie LIU ; Jie ZENG ; Yalan LEI ; Xiaofeng WEN ; Ming XIA ; Hong SUN
Keywords: Atosiban; Repeated implantation failure; Thawed embryo transfer; Clinical pregnancy rate
From: The Journal of Practical Medicine 2017;33(6):979-982
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of atosiban on the pregnancy outcome in patients with repeated implantation failure(RIF)in blastcyst thawed embryo transfer(bTET) Methods From January 2014 to December 2015,a total of 262 RIF patients undergoing bTET were retrospectively studied. They were divided into study group with a single bolus dose (6.75 mg/0.9 mL,iv) of atosiban before bTET (n = 94),and control groupwithout atosiban(n = 168). Results The clinical pregnancy rate(57.41%),implantation rate(38.41%) and living-birth rate(46.81%) of study group were significantly higher than those of control group (41.12%, 28.32% and 33.93% respectively;P < 0.05). Although the abortion rate of study group was higher than that of control group(14.82% vs 13.04%),both the ectopic pregnancy rate(3.70%) and the multiple pregnancy rate (16.67%) were lower than those of control group(5.79% and 17.39%),and there was no statistical difference (P > 0.05). Conclusion Atosiban treatment before embryo transfer may improve pregnancy outcomes of RIF patients in bTET.