The clinical research of Tanshinone type ⅡA sulfonate on preventing hepatic artery thrombosis after liver transplantation
10.3760/cma.j.issn.1673-4246.2017.05.006
- VernacularTitle:丹参酮ⅡA磺酸钠对肝移植术后肝动脉血栓形成的影响
- Author:
Ting XIANG
;
Yang CHONG
;
Donghua ZHANG
;
Tao JIANG
;
Xuan WANG
- Keywords:
Liver transplantation;
Postoperative complications;
Tanshinone ⅡA sodium sulfonate;
Hepatic artery thrombosis;
Clinical study
- From:
International Journal of Traditional Chinese Medicine
2017;39(5):408-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clnical effects of influence of tanshinone type ⅡA sulfonate on preventing hepatic artery thrombosis after transplantation.Methods A total of 60 patients after liver transplantation were randomly individed into the treatment group and control group, each 30 patients. The treatment group received tanshinone ⅡA sodium sulfonate treatment (60 mg qd, ivgtt continuous 10d) , while the control group used conventional heparinization. The blood coagulation index and the thrombelastograph variables were detected after 7 days and the hepatic artery resistance index (RI) was detected by using Doppler ultrasonography. The postoperative complications and mortality rates were analyzed.Results Although it had little improvement on the coagulation function after liver transplantation, tanshinone ⅡA sodium sulfonate had significant improvement on the time of thrombelastograph parameters reaction (6.35 ± 1.59 minvs. 5.21 ± 1.37 min,t=2.453) and maximum amplitude (58.07 ± 5.42 mmvs. 61.67 ± 5.63 mm,t=-2.532). It showed that RI have significantly statistical difference between the two groups after treatment (0.73 ± 0.11vs. 0.62 ± 0.10;t=-2.948,P<0.01). During the trial, the control group had 2 cases of postoperative complications, HAT and bleeding.Conclusions The Tanshinone ⅡA sodium after liver transplantation can improve the clotting mechanism, preventing HAT.
