Research of the clinical effect and immune regulatory mechanism of red blue light combined with Niuhuang-Shangqing capsules for the moderate-severe acne
10.3760/cma.j.issn.1673-4246.2017.05.008
- VernacularTitle:红蓝光联合牛黄上清胶囊治疗中重度痤疮的临床研究
- Author:
Yanfen YE
;
Jiehua LI
;
Shubin ZHONG
;
Wanyun ZHOU
- Keywords:
Acne vulgaris;
Color therapy;
Niu Huang Shang Qing capsule;
Adjuvants;
immunologic;
Comparative effectiveness research
- From:
International Journal of Traditional Chinese Medicine
2017;39(5):416-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the the clinical effect and immune regulatory mechanism of red-blue light combined with Niuhuang Shangqing capsules for the moderate-severe acne.Methods A total of 180 patients with moderate to severe acne treated in People's Hospital of Nanhai District in Foshan City from June 2014 to June 2016 were randomly divided into 2 groups with each group 90 patients. The control group was treated with red and blue light, and observation group was treated with the combination of red and blue light andNiuhuang-Shangqingcapsules. The levels of SP(Substance P), IL-1 and IL-6 in peripheral blood were observed and analyzed. The recurrence rates and adverse events were observed.Results After treatment, the SP (657.4 ± 36.6 pg/mlvs.799.9 ± 60.2 pg/ml,t=19.188), IL-1(61.8 ± 24.7pg/L vs.92.1 ± 23.5 pg/L,t=8.431), IL-6 (38.7 ± 10.3pg/mlvs.66.7 ± 14.1pg/ml, t=12.421) of the observation group were significantly better than those of the control group (allPs<0.01). The total effect rate of the observation group were 91.11% (82/90), which were significantly higher than 70.00% (63/90) of control group (χ2=12.804,P<0.01). Conclusions The Red-blue light combined withNiuhuang-Shangqing capsules for treating moderate-severe acne, has significant effect and can reduce the serum levels of SP, IL-1 and IL-6, with fewer adverse events and lower recurrence rates. They can be used as a safe and effective treatment of acne.
