Clinical analysis of autologous peripheral blood hematopoietic stem cell mobilization regimen in 61 lymphoma patients
10.3969/j.issn.1000-8179.2017.08.442
- VernacularTitle:61例淋巴瘤患者自体外周血造血干细胞动员方案临床分析
- Author:
Chaoyu WANG
;
Bing XIA
;
Wen XU
;
Chen TIAN
;
Haifeng ZHAO
;
Hongliang YANG
;
Zhigang ZHAO
;
Xiaofang WANG
;
Yafei WANG
;
Yong YU
;
Yizhuo ZHANG
- Keywords:
malignant lymphoma;
autologous peripheral blood stem cell transplantation;
mobilization;
granulocyte colony-stimulating factor;
granulocyte-macrophage colony-stimulating factor
- From:
Chinese Journal of Clinical Oncology
2017;44(8):377-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy between chemotherapy with granulocyte colony-stimulating factor (G-CSF) and chemo-therapy with G-CSF and granulocyte-macrophage colony-stimulating factor (GM-CSF) for the mobilization of peripheral blood hemato-poietic stem cells and hematological recovery post-transplantation in patients with malignant lymphoma. Methods:Autologous pe-ripheral blood hematopoietic stem cell mobilization data of 61 malignant lymphoma patients who were treated with chemotherapy plus G-CSF or chemotherapy plus G-CSF and GM-CSF from May 2008 to October 2016 were included in this study. The mobilization effi-cacy and hematopoietic recovery were analyzed. Results:During mobilization, White blood cells (WBC) of all patients decreased to 1.0×109/L and platelets (PLT) dropped to 40×109/L. The successful mobilization rates of CD34+cell are 52.5%in chemotherapy plus G-CSF group and 90.5%in chemotherapy plus G-CSF+GM-CSF group (P=0.003). All patients successfully underwent hematopoietic recon-struction without transplantation-related mortality. Conclusion: Although chemotherapy with G-CSF+GM-CSF can significantly in-crease the effect of autologous peripheral blood hematopoietic stem cell mobilization, the reconstruction of hematopoietic function after transplantation and side reaction between the two groups are the same. Thus, chemotherapy with G-CSF+GM-CSF is not superior to chemotherapy with G-CSF in mobilizing autologous peripheral blood hematopoietic stem cells.
